BME Seminar Series
Presents

Klaus Ley, M.D.
Professor of Biomedical Engineering
Director of the Cardiovascular Research Center
University of Virginia

Translational Research in Cardiovascular Medicine

Friday, October 5, 2007
2:00 - 3:00 p.m.
BME Lecture Hall (Room 1041), MR-5

ABSTRACT
Cardiovascular medicine encompasses the clinical disciplines of cardiology and thoracic and cardiovascular surgery. Cardiovascular research includes basic, applied and translational research, where translational is defined as research that brings discovery directly from the bench to practical applications in patients (www.sickkids.ca/prm/section.asp). The challenge is "bridging the gap" between doctors, who have patients with interesting diseases and who primarily care about outcomes, scientists, who primarily care about mechanisms, and engineers, who primarily are interested in making things work. Together with many investigators at UVA, my own work has touched on basic discovery & understanding, therapeutic and diagnostic target identification, synthesis of drug or development of prototype device or process, preclinical testing, and human testing in clinical trials. I will give examples in the areas of selectins, ischemia and reperfusion, chemokines, integrins and their ligands, molecular ultrasound imaging, cell tracking, proteomics, and findings with translational potential. .