Richard J. Price
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Associate Professor of Biomedical Engineering
B.S., Rochester Institute of Technology, 1990
M.S., Biomedical Engineering, University of Virginia, 1992
Ph.D., Biomedical Engineering, University of Virginia, 1995
Department of Biomedical Engineering
University of Virginia
Box 800759 Health System
Charlottesville, VA 22908
rprice@virginia.edu
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Research Interests
Ultrasound Targeted Delivery of Nanoparticle Drug and Gene Carriers
The targeted delivery of intravascularly injected genes and drugs to
specific regions deep within the body remains a significant challenge
in the treatment of many pathological conditions. To address this
problem, we are developing ultrasound-activated drug delivery systems
that are comprised of various combinations of biodegradable polymer
nanoparticles and contrast agent microbubbles. As these agents pass
through an ultrasound-targeted region, the microbubble components
oscillate and induce microvessel permeabilization which then
facilitates the deposition of the controlled-release drug-bearing
nanoparticles in the tissue. In pre-clinical studies, we are using
these ultrasound-activated drug delivery systems for restoring blood
flow to ischemic tissue via growth factor delivery and therapeutic
arteriogenesis and for treating brain tumors via enhanced
chemotherapeutic drug deposition.
Regulation of Microvascular Structure by Hemodynamic Forces and Bone Marrow-Derived Cells
The formation of new microvessel networks is a critically important
event in many normal and pathological adaptations. Proper network
assembly involves the formation of new capillaries and the subsequent
investment of these new capillaries with perivascular smooth muscle
cells. At present, the laboratory is primarily focused on
understanding the regulation of microvascular growth and structure
during inflammation and wound healing through the use of numerous
transgenic, knockout, and chimeric mouse models. Specific projects are
aimed at determining how VEGF and shear stress regulate endothelial
cell phenotype and function during capillary sprouting and how the
chemokine-selective recruitment of bone marrow-derived cell
subpopulations affects microvascular blood vessel growth through
differential paracrine growth factor signaling.
Selected Publications
Chappell JC, Song J, Burke CW, Klibanov AL, Price RJ.
Targeted delivery of nanoparticles bearing fibroblast growth factor-2
by ultrasonic microbubble destruction for therapeutic arteriogenesis.
Small. 2008 Oct;4(10):1769-1777.
Anderson CR, Hastings NE, Blackman BR, Price RJ.
Capillary sprout
endothelial cells exhibit a CD36 low phenotype: regulation by shear
stress and vascular endothelial growth factor-induced mechanism for
attenuating anti-proliferative thrombospondin-1 signaling.
Am J Pathol. 2008 Oct;173(4):1220-8.
Chappell JC, Song J, Klibanov AL, Price RJ.
Ultrasonic microbubble destruction stimulates therapeutic
arteriogenesis via the CD18-dependent recruitment of bone
marrow-derived cells.
Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1117-22.
Van Gieson EJ, Murfee WL, Skalak TC, Price RJ.
Enhanced smooth muscle cell coverage of microvessels exposed to
increased hemodynamic stresses in vivo.
Circ Res. 2003 May 2;92(8):929-36.
Song J, Qi M, Kaul S, Price RJ.
Stimulation of arteriogenesis in skeletal muscle by microbubble destruction with ultrasound.
Circulation. 2002 Sep 17;106(12):1550-5.
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