Richard J. Price
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Associate Professor of Biomedical Engineering
B.S., Rochester Institute of Technology, 1990
M.S., Biomedical Engineering, University of Virginia, 1992
Ph.D., Biomedical Engineering, University of Virginia, 1995
Department of Biomedical Engineering
University of Virginia
Box 800759 Health System
Charlottesville, VA 22908
rprice@virginia.edu
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Research Interests
Microvascular Network Patterning
The formation of new microvessel networks is a critically important
event in many normal and pathological adaptations. Proper network
assembly involves formation of new capillaries then investment of
these new capillaries with perivascular or smooth muscle cells. Our
research seeks to understand how molecular signals, hemodynamic
stresses, and the underlying extracellular matrix coordinate the
assembly of these networks. Specifically, the laboratory is studying
how migrating vascular cells are guided by matrix protein scaffolds
and how the process of capillary investment with perivascular cells is
controlled by signaling molecules produced by capillary wall cells in
response to alterations in blood pressure and flow.
Contrast Ultrasound Therapeutics
The delivery of genes and drugs encased in liposomes to specific
regions of the body is often hindered by the endothelial lining of
microvessels. We have observed that, under certain conditions,
insonified albumin shelled microbubbles can produce pores in small
skeletal muscle microvessels that allow intravascular gene and drug
bearing particles to pass across the endothelial lining in
ultrasonically targeted regions in the body. Ongoing studies are aimed
at determining optimal ultrasound parameters for the targeted delivery
of gene and drug bearing particles and testing the ability of
ultrasound-microbubble interactions to restore blood flow to ischemic
tissue via therapeutic arteriogenesis.
Selected Publications
Chappell JC, Song J, Burke CW, Klibanov AL, Price RJ.
Ultrasound-Microbubble-Targeted Delivery of FGF2-Bearing Nanoparticles
for Therapeutic Arteriogenesis.
Small. 2008. DOI:10.1002/smll.200800806.
Song J, Klibanov AL, Hossack JA, Price RJ.
Acoustic attenuation by contrast agent microbubbles in superficial
tissue markedly diminishes petechiae bioeffects in deep tissue.
Invest Radiol. 2008 May;43(5):322-9.
Chappell JC, Song J, Klibanov AL, Price RJ.
Ultrasonic microbubble destruction stimulates therapeutic
arteriogenesis via the CD18-dependent recruitment of bone
marrow-derived cells.
Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1117-22.
Van Gieson EJ, Murfee WL, Skalak TC, Price RJ.
Enhanced smooth muscle cell coverage of microvessels exposed to
increased hemodynamic stresses in vivo.
Circ Res. 2003 May 2;92(8):929-36.
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