Jeffrey W. Holmes
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Associate Professor of Biomedical Engineering and Medicine
B.S., Biomedical Engineering, The Johns Hopkins University, 1989
Ph.D., Bioengineering, UCSD, 1995
M.D., UCSD, 1998
Biomedical Engineering
Box 800759
University of Virginia
Charlottesville, Virginia 22908
holmes@virginia.edu |
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Research Interests
The Cardiac Biomechanics Group focuses on the interactions between
mechanics, function, and growth and remodeling in the heart. The
mechanical properties of normal and diseased myocardium are important
determinants of overall heart function. These mechanical properties
change during growth, remodeling or disease, often in part as a
response to changes in the mechanical environment. Our group studies
this interplay between mechanical environment, tissue response, and
heart function, not only to better understand the basis for heart
disease but also to identify new opportunities to intervene.
Current Projects:
Currently, most of our projects are related to myocardial infarction (MI):
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a translational effort to help prevent MI by developing new
quantitative measures of heart wall motion that improve screening for
coronary artery disease;
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a basic biomechanics project focused on understanding how the
structure of a healing infarct gives rise to its mechanical properties
and how those mechanical properties influence overall heart function;
and
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longer-term efforts to determine how mechanical factors regulate
both cardiac wound healing and remodeling of non-infarcted myocardium
in post-MI patients
Selected Publications
Thomopoulos S, Fomovsky GM, Chandran PL, Holmes JW.
Collagen fiber structure does not explain mechanical anisotropy in
fibroblast populated collagen gels.
J Biomech Eng, in press.
Ingrassia CM, Usyk TP, Kerckhoffs RCP, McCulloch AD, Costa KD, Holmes JW.
Model-based development of 4-dimensional wall motion measures.
Comp Meth Appl Mech Eng, published online before print
February 15, 2007; doi:10.1016/j.cma.2006. 06.016).
Holmes JW.
Teaching from the classics: A.V. Hill.s model of muscle
contraction.
Adv Physiol Educ, 30(2):67-72, 2006.
Thomopoulos S, Fomovsky GM, Holmes JW.
The development of structural and mechanical anisotropy in fibroblast
populated collagen gels.
J Biomech Eng, 127(5):742-750, 2005.
Herz SL, Ingrassia CM, Homma S, Costa KD, Holmes JW.
Parameterization of left ventricular wall motion for detection of regional
ischemia.
Ann Biomed Eng, 33(7):920-927, 2005.
Holmes JW, Borg TK, Covell JW.
Structure and mechanics of healing myocardial infarcts.
Ann Rev Biomed Eng 7:223-253, 2005.
PubMed listings for this faculty member
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