Botchwey Laboratory

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Publications

Neal RA, Oredein-McCoy O, and Botchwey EA. Nanotechnologies for Cardiovascular Tissue Engineering. In Nanotechnology and Tissue Engineering, the Scaffold. CT Laurencin and L Nair, eds. CRC Press/Taylor and Francis. In press.

Wieghaus KA, Gianchandani EP, Neal RA, Paige MA, Brown ML, Papin JA, Botchwey EA. Phthalimide neovascular factor 1 (PNF1) modulates MT1-MMP activity in human microvascular endothelial cells. Biotechnol Bioeng. 2009 Jul 1;103(4):796-807. [Pubmed | Fulltext]

Petrie Aronin CE, Sadik KW, Lay AL, Rion DB, Tholpady SS, Ogle RC, Botchwey EA.Comparative effects of scaffold pore size, pore volume, and total void volume on cranial bone healing patterns using microsphere-based scaffolds. J Biomed Mater Res A. 2009 Jun;89(3):632-41. [Pubmed | PDF]

Neal RA, McClugage SG, Link MC, Sefcik LS, Ogle RC, Botchwey EA. Laminin nanofiber meshes that mimic morphological properties and bioactivity of basement membranes. Tissue Eng Part C Methods. 2009 Mar;15(1):11-21. [Pubmed | PDF]

Wieghaus KA, Nickerson MM, Petrie Aronin CE, Sefcik LS, Paige M, Price RJ, Brown ML, Botchwey EA. Expansion of microvascular networks in vivo by phthalimide neovascular factor 1 (PNF1). Biomaterials. 2008. 29(35):2698-708. [PubMed | PDF]

Sefcik LS, Petrie Aronin CE, Botchwey EA. Engineering vascularized tissues using natural and synthetic small molecules. Organogenesis. 2008. 4(4):215-227. [Pubmed | PDF]

Sefcik LS, Petrie Aronin CE, Wieghaus KA, Botchwey EA. Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering. Biomaterials. 2008 Jul;29(19):2869-77. [PubMed | PDF]

Sefcik LS, Neal RA, Kaszuba SN, Parker AM, Katz AJ, Ogle RC, Botchwey EA. Collagen nanofibres are a biomimetic substrate for the serum-free osteogenic differentiation of human adipose stem cells. J Tissue Eng Regen Med. 2008 Jun; 2(4):210-20. [PubMed | Abstract | PDF]

Petrie Aronin CE, Sadik KW, Lay AL, Rion DB, Tholpady SS, Ogle RC, Botchwey EA. Comparative effects of scaffold pore size, pore volume, and total void volume on cranial bone healing patterns using microsphere-based scaffolds. J Biomed Mater Res A. 2008 Apr 28. [PubMed | Abstract | Full Text]

Petrie Aronin CE, Cooper JA Jr, Sefcik LS, Tholpady SS, Ogle RC, Botchwey EA. Osteogenic differentiation of dura mater stem cells cultured in vitro on three-dimensional porous scaffolds of poly(epsilon-caprolactone) fabricated via co-extrusion and gas foaming. Acta Biomater. 2008 Mar 18. [PubMed | Full Text | PDF]

Wieghaus KA, Gianchandani EP, Brown ML, Papin JA, Botchwey EA. Mechanistic exploration of phthalimide neovascular factor 1 using network analysis tools. Tissue Eng. 2007 Oct;13(10):2561-75. [PubMed | Abstract | PDF]

Petrie C, Tholpady S, Ogle R, Botchwey E. Proliferative capacity and osteogenic potential of novel dura mater stem cells on poly-lactic-co-glycolic acid. J Biomed Mater Res A. 2007 Aug 9; [Epub ahead of print]. [PubMed | Abstract | Full Text]

Wieghaus KA, Capitosti SM, Anderson CR, Price RJ, Blackman BR, Brown ML, Botchwey EA. Small molecule inducers of angiogenesis for tissue engineering. Tissue Eng. 2006 Jul;12(7):1903-13. [PubMed | Abstract | PDF]

Laurencin CT, Khan Y, Kofron M, El-Amin S, Botchwey E, Yu X, Cooper JA Jr. The ABJS Nicolas Andry Award: Tissue engineering of bone and ligament: a 15-year perspective. Clin Orthop Relat Res. 2006 Jun;447:221-36. [PubMed | Abstract | Full Text | PDF]

El-Amin SF, Botchwey E, Tuli R, Kofron MD, Mesfin A, Sethuraman S, Tuan RS, Laurencin CT. Human osteoblast cells: isolation, characterization, and growth on polymers for musculoskeletal tissue engineering. J Biomed Mater Res A. 2006 Mar 1;76(3):439-49. [PubMed]

Wieghaus KA, Capitosti SM, Brown ML, and Botchwey EA. Novel angiogenic compounds for targeted drug delivery. Materials Research Society Symposium Proceedings, Volume 845: Nanoscale Materials Science in Biology and Medicine. December 2004. [Abstract]

Yu X, Botchwey EA, Levine EM, Pollack SR, Laurencin CT. Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization. Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11203-8. [PubMed | Abstract | Full Text | PDF]

Botchwey EA, Pollack SR, Levine EM, Johnston ED, Laurencin CT. Quantitative analysis of three-dimensional fluid flow in rotating bioreactors for tissue engineering. J Biomed Mater Res A. 2004 May 1;69(2):205-15. [PubMed | Abstract | Full Text | PDF]

Botchwey EA, Dupree MA, Pollack SR, Levine EM, Laurencin CT. Tissue engineered bone: measurement of nutrient transport in three-dimensional matrices. J Biomed Mater Res A. 2003 Oct 1;67(1):357-67. [PubMed | Abstract | Full Text | PDF]

Botchwey EA, Pollack SR, El-Amin S, Levine EM, Tuan RS, Laurencin CT. Human osteoblast-like cells in three-dimensional culture with fluid flow. Biorheology. 2003;40(1-3):299-306. [PubMed | Abstract]

Botchwey EA, Pollack SR, Levine EM, Laurencin CT. Bone tissue engineering in a rotating bioreactor using a microcarrier matrix system. J Biomed Mater Res. 2001 May;55(2):242-53. [PubMed | Abstract | Full Text | PDF]

Laurencin CT, Lipson SJ, Senatus P, Botchwey E, Jones TR, Koris M, Hunter J. The stenosis ratio: a new tool for the diagnosis of degenerative spinal stenosis. Int J Surg Investig. 1999;1(2):127-31. [PubMed]

Laurencin C, Attawia M, Botchwey E, Warren R, Attia E. Cell-material systems for anterior cruciate ligament regeneration. In Vitro Cell Dev Biol Anim. 1998 Feb;34(2):90-2.

Attawia MA, Uhrich KE, Botchwey E, Langer R, Laurencin CT. In vitro bone biocompatibility of poly (anhydride-co-imides) containing pyromellitylimidoalanine. J Orthop Res. 1996 May;14(3):445-54. [PubMed | Abstract]

Attawia MA, Uhrich KE, Botchwey E, Fan M, Langer R, Laurencin CT. Cytotoxicity testing of poly(anhydride-co-imides) for orthopedic applications. J Biomed Mater Res. 1995 Oct;29(10):1233-40. [PubMed]